CDK6 degradation hits Ph+ ALL hard
نویسندگان
چکیده
منابع مشابه
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Cyclin-dependent kinase 6 (Cdk6) is a D-Cyclin-activated kinase that is directly involved in driving the cell cycle through inactivation of pRB in G₁ phase. Increasingly, evidence suggests that CDK6, while directly driving the cell cycle, may only be essential for proliferation of specialized cell types, agreeing with the notion that CDK6 also plays an important role in differentiation. Here, e...
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Standard search techniques for DNA repeats start by identifying seeds, that is, small matching words, that may inhabit larger repeats. Recent innovations in seed structure have led to the development of spaced seeds [8] and indel seeds [9] which are more sensitive than contiguous seeds (also known as k-mers, k-tuples, l-words, etc.). Evaluating seed sensitivity requires 1) specifying a homology...
متن کاملAll hits all the time: parameter-free calculation of spaced seed sensitivity
MOTIVATION Standard search techniques for DNA repeats start by identifying small matching words, or seeds, that may inhabit larger repeats. Recent innovations in seed structure include spaced seeds and indel seeds which are more sensitive than contiguous seeds. Evaluating seed sensitivity requires (i) specifying a homology model for alignments and (ii) assigning probabilities to those alignment...
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In analogy with NP, a language L is in the class NQP if the strings in L are exactly those accepted by a polynomial-time quantum machine with non-zero probability. Previously, Adleman, Demarrais and Huang showed that NQP PP. The sharper upper bound NQP coC=P is implicit in Adleman et al. and results of Fortnow and Rogers. Here we prove that in fact NQP and coC=P are the same class, by showing t...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.2020005136